BLS metro-level wage data places Nurse Practitioners pay in Cape Girardeau, MO-IL at a median of $130,000 per year ($62.50/hr/hour), drawn from the OEWS May 2025 release for this Metropolitan Statistical Area. Compared to the national median of $132,300, Cape Girardeau pays 2% below, which typically tracks with a lower local cost of living or smaller specialized-employer cluster. Approximately 200 nurse practitionerss are employed across the Cape Girardeau MSA in SOC 29-1171.

The Cape Girardeau pay distribution spans from $97,350 at the 10th percentile to $149,020 at the 90th — a 1.5× spread that reflects experience tenure, specialization, employer size, and the difference between public-sector, nonprofit, and private-sector compensation inside the metro. The 25th percentile sits at $119,500 and the 75th at $139,690, so half of Cape Girardeau-based nurse practitionerss earn within that middle band.

Metro figures capture where you actually work, not just where you live — which matters for commuters. BLS draws metro boundaries from the OMB MSA definitions, so Cape Girardeau, MO-IL covers the central city plus outlying counties tied to the metro economically. Remember that OEWS wages reflect base pay only: employer-provided health insurance, retirement matches, stock options, signing bonuses, overtime, and tips are excluded and can add 20-40% to real total compensation. Before using this metro median as a negotiation anchor, triangulate against the same occupation's national profile (linked below), its state-wide MO data, and peer-metro comparisons — a median is a starting point, not a ceiling.