BLS metro-level wage data places Registered Nurses pay in Greenville-Anderson-Greer, SC at a median of $81,400 per year ($39.14/hr/hour), drawn from the OEWS May 2025 release for this Metropolitan Statistical Area. Compared to the national median of $97,550, Greenville-Anderson-Greer pays 17% below, which typically tracks with a lower local cost of living or smaller specialized-employer cluster. Approximately 9,730 registered nursess are employed across the Greenville-Anderson-Greer MSA in SOC 29-1141.

The Greenville-Anderson-Greer pay distribution spans from $68,530 at the 10th percentile to $100,630 at the 90th — a 1.5× spread that reflects experience tenure, specialization, employer size, and the difference between public-sector, nonprofit, and private-sector compensation inside the metro. The 25th percentile sits at $78,060 and the 75th at $96,580, so half of Greenville-Anderson-Greer-based registered nursess earn within that middle band.

Metro figures capture where you actually work, not just where you live — which matters for commuters. BLS draws metro boundaries from the OMB MSA definitions, so Greenville-Anderson-Greer, SC covers the central city plus outlying counties tied to the metro economically. Remember that OEWS wages reflect base pay only: employer-provided health insurance, retirement matches, stock options, signing bonuses, overtime, and tips are excluded and can add 20-40% to real total compensation. Before using this metro median as a negotiation anchor, triangulate against the same occupation's national profile (linked below), its state-wide SC data, and peer-metro comparisons — a median is a starting point, not a ceiling.